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Elanco Animal Health(NYSE: ELAN)
Q1 2024 Earnings Call
May 08, 2024, 8:00 a.m. ET
Contents:
- Prepared Remarks
- Questions and Answers
- Call Participants
Prepared Remarks:
Operator
Ladies and gentlemen, thank you for standing by. Welcome, everyone, to the Elanco Animal Health first-quarter 2024 earnings conference call. At this time, all lines have been placed on mute to prevent any background noise. After the speakers' remarks, there will be a question-and-answer session.
[Operator instructions] Thank you. I would now like to hand the call over to Katy Grissom, head of investor relations. You may begin your conference.
Katy Grissom -- Head of Investor Relations
Good morning. Thank you for joining us for Elanco Animal Health's first-quarter 2024 earnings call. I'm Katy Grissom, head of investor relations. Joining me on the call today are Jeff Simmons, our president and chief executive officer; Todd Young, our chief financial officer; and Scott Purucker from investor relations.
The slides referenced during this call are available on the Investor Relations section of elanco.com. Today's discussion will include forward-looking statements. These statements are based on our current assumptions and expectations and are subject to risks and uncertainties that could cause actual results to differ materially from our forecast. For more information, see the risk factors discussed in today's earnings press release as well as the latest Form 10-K and 10-Q filed with the SEC.
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We do not undertake any duty to update any forward-looking statements. Our remarks today will focus on our non-GAAP financial measures. Reconciliations of these non-GAAP measures are included in the appendix of today's slides and in the earnings press release. After our prepared remarks, we'll be happy to take your questions.
I'll now turn the call over to Jeff.
Jeff Simmons -- President and Chief Executive Officer
Thanks, Katy. Good morning, everyone. Elanco is poised for a very exciting 2024. Our strong business momentum continued in the first quarter, reinforced by the diversity of our portfolio and geographic results.
In the quarter, we exceeded the top end of our guidance range on our key metrics, revenue, adjusted EBITDA, and adjusted EPS. We are encouraged by the strong progress of our late-stage pipeline, which has advanced significantly over the last several months. The One Elanco approach to collaboration and decision-making is driving positive and productive outcomes across the world. Energy, resiliency, and creativity are filling our halls and permeating our conversations with customers.
Our focus for the year remains on growth, innovation, and cash, with many proof points to start the year. Beginning on Slide 4. Our underlying business is off to a very encouraging start in 2024. As you may remember, our quarterly results in the first half of last year were impacted by a shift in customer purchasing related to our ERP system integration from the second quarter into the first quarter of 2023.
As determined last year, we estimate the shift was $90 million to $110 million. I will focus my comments on our underlying growth, excluding the estimated impact of the shift. For the first quarter, underlying revenue growth continued in the mid single-digit range, estimated at 3% to 5% in the first quarter, building on the 5% constant-currency growth in both the third and fourth quarters last year. We remain confident in our late-stage innovation.
Based on our dialogue with the FDA and the status of the packages submitted, we have increased certainty in the expected approval timing for Bovaer, Zenrelia and Credelio Quattro. We continue to expect to bring differentiated products to the market, with revenue contribution expected from all three products in the second half of the year. On cash in the quarter, we reduced net debt and improved operating cash flow by nearly $150 million year over year, as a result of our disciplined focus on improving net working capital and the benefit of completing our ERP system integration. We reduced balance sheet inventory even as we built inventory for new products.
We continue to expect the sale of our aqua business to close around midyear. Finally, we're increasing our expectations for constant-currency revenue growth for the full year, now at 2% to 3% growth. We are updating our key guidance metrics to reflect the unfavorable impact of increased strength of the U.S. dollar since February, with constant-currency expectations improving on both adjusted EBITDA and adjusted EPS.
Moving to Slide 5. I'll review our business performance in the first quarter. We delivered revenue of $1.205 billion, with both sides of our business performing well in the first quarter. For pet health, we estimate constant-currency underlying growth was 5% to 7% globally.
This includes approximately 3% underlying revenue growth in the U.S. with improved supply and increased innovation sales, partially offset by competitive and macro headwinds. Reduced consumer activity as a result of adverse weather was felt in the industry in January, and as expected, dispensing improved sequentially in both February and March as we see this momentum also carrying into the second quarter. Our OTC retail business is performing well.
Based on our market analysis of the retail channel, our advantage classic brands for dogs and cats were both top $3 growth brands in the quarter. Our portfolio has benefited from the increased physical availability and higher-than-expected overall market share for the advantage family and retail channels. In addition, we're encouraged by Seresto. Our investment in a new, bold DTC advertising campaign this season drove a five-point improvement in unaided awareness for the brand.
This is an important leading indicator to share growth. Broadly across our OTC portfolio, we are leveraging our market leadership to drive growth by implementing key initiatives in-store and online across brands and retailers as we enter the heart of the North American parasiticide season. In the U.S. vet clinic market, visits continue to be pressured primarily as a result of labor and capacity constraints.
Despite this impact and continued competitive innovation, the consistent execution of our strategy is strengthening Elanco's position, driving in line or better-than-expected market share performance. Our expanded vet sales force has significantly increased our share voice, an important leading indicator expected to lift the portfolio as the year progresses. Additionally, our innovation is elevating the relevance of our portfolio. We are focused on enhancing our partnership with strategic corporate accounts, while also investing in key platforms used by the veterinarians.
Our Canine Parvovirus Monoclonal Antibody, or CPMA, continues to ramp, with sales improving sequentially each month to start the year. In late April, we launched a new marketing campaign geared toward both pet owners and veterinarians to raise awareness of the virus, how it spreads, and the effectiveness of Elanco's breakthrough treatment. These efforts include the first-ever online parvo tracking tool, empowering pet owners and the veterinary community with game-changing intelligence to help keep puppies safe. With expanded supply capacity, we are enhancing our targeting efforts to drive penetration.
Early data shows when clinics have the product in the freezer, outcomes for puppies, pet owners, and the clinic staff are improved, leading to reordering. We expect continued ramp for the product throughout the year. Now, moving to international pet health, where we estimate underlying constant-currency revenue growth was approximately 9% in the first quarter on a year-over-year basis. In line with our expectations, growth was driven by improved demand for OTC parasiticide products, led by Seresto in certain European markets, including Spain.
Additionally, we continue to see increased demand for the Credelio family and a strong ramp for AdTab in Europe. We are meaningfully investing in the launch of AdTab, including point-of-sale as well as digital and traditional direct-to-consumer advertising, which is permitted for OTC products in the region. Employing the same principles as the U.S., our strategic focus on physical availability and share of voice is driving a strong launch curve with limited cannibalization of our existing leading portfolio of collars and topicals in Europe. Now, shifting to farm animal.
Globally, we estimate underlying constant-currency revenue growth was 1% to 2%. In the U.S., approximately 11% of underlying growth was driven by poultry and cattle. In poultry, we benefited from the rotations and extended use of our products in the quarter. Going forward this year, we expect increased use of our ionophores as the market continues to shift from No Antibiotics Ever programs to no antibiotics important to human medicine programs.
In cattle, while there was a slight uptick in cattle on feed in March, we continue to see increased days on feed, broadly benefiting our medicated feed additive portfolio in beef. Medicated feed additives are the cornerstone of Elanco's diverse farm animal portfolio, and innovation is enabling us to gain market share at this opportune time. We continue to be pleased with the trajectory of Experior in the U.S. Continued adoption and expected increased use in heifers in the U.S., as well as the strength in Canada, is giving us increased confidence that the product will approach blockbuster status globally in 2024.
The demand for Elanco's livestock sustainability portfolio with Experior and anticipation of Bovaer is driving sales growth for Rumensin across both beef and dairy, further insulating one of our largest brands. And finally, for our farm animal business outside the U.S., we estimate a decline of approximately 2%. Continued demand growth for poultry was more than offset by volatility in China, notably in swine, and we continue to take a cautious approach with regards to our expectations in China for the year. Overall, in the first quarter for our global business, our launched innovation and base portfolio growth drivers delivered.
We have raised our expectations for the full-year constant-currency revenue growth to 2% to 3%, before the contributions of our late-stage pipeline. Moving now to Slide 6. We made progress across our innovation, portfolio, and productivity strategy in the first quarter. On portfolio, we saw 2% price growth, and the core business continues to stabilize.
Regarding productivity, operating cash flow improved, and the first quarter restructuring and Aqua divestiture are progressing as planned. Now, let's get into innovation starting on Slide 7. In late 2020, we shared our expectations to deliver high-impact innovation to the market by 2025. Over the last three years, we have delivered over 10 innovations, in addition to numerous regional products and life cycle management improvements.
Importantly, we remain on track to generate an expected $600 million to $700 million of revenue from new product innovations in 2025. Moving to Slide 8. Launched new products led by Experior, NutriQuest, AdTab, Credelio Plus, and Credelio Cat are performing in line with or better than expectations. This portfolio delivered $275 million in 2023, more than doubling 2022.
Today, we're introducing a new quarterly disclosure of our innovation sales. In the first quarter, new product sales contributed $100 million. We now expect this basket of products to deliver $375 million to $410 million for this year, excluding any contribution from our late-stage pipeline. We are encouraged by the contribution of our innovation already in the market and are thrilled that the next phase of our historic launch window is right in front of us.
As we have shared previously, the U.S. regulatory process is rolling and iterative. We have had productive engagement with the FDA Center for Veterinary Medicine over the last several years and more specifically the last several months on all three key late-stage programs. Since we started submissions for these products in late 2022, the majority of the technical sections and subsections have been approved by the agency, and we continue to be very confident in the approvability of these differentiated products.
Moving to Slide 9. Both Zenrelia and Credelio Quattro have progressed since February, and we believe the FDA has all the data necessary to complete its review of these products. For both products, we expect that all technical sections, including labels, will be approved by the FDA before the end of June. After the approval of all technical sections, each New Animal Drug Application, or NADA, undergoes an expected 60-day final administrative review, putting our full approval expectations in Q3.
Now, a little more on each product specifically. Zenrelia is our JAK inhibitor, targeting the control of pruritus and atopic dermatitis in dogs at least 12 months of age. We remain confident this product will be differentiated from the current market option. Our market research shows clear interest and desire for additional options as we will continue to prioritize the optimization of the label to provide the most meaningful differentiation.
We expect to have a very efficient approval-to-launch window, targeting product in the market before the end of the third quarter. Additionally, we expect approval for Zenrelia in several international markets starting late in 2024, our fastest globalization effort ever. Now, moving to Credelio Quattro, our broad-spectrum parasiticide targeting coverage for fleets, ticks, heartworms, and other internal parasites in a single monthly dose. As we have shared previously, we expect Quattro will be differentiated from incumbent products in the market, with broader coverage.
Specifically, we expect to have coverage of tape worms, including those known to be zoonotic or posing risk to humans that cannot effectively be prevented by eliminating fleets. We expect this broader coverage and the ability to prevent heartworms after the first monthly dose that we are seeking to demonstrate to the FDA will position Credelio Quattro uniquely in the market. For Quattro, we're targeting launch in the fourth quarter of this year. Finally, Bovaer, our first-in-class methane-reducing feed ingredient for the U.S.
dairy market, is in the final stage of review with the FDA with completion expected before the end of May. We appreciate the FDA's commitment to maintaining high standards for risk and science-based review, while balancing the need to quickly bring solutions to the market. The regulatory process for Bovaer underscores the need for the FDA's innovation agenda to modernize our regulatory process. We are continuing to help shape the ecosystem for an in-set carbon market to support progression toward the opportunity for climate-neutral farming, while also creating a revenue stream for dairy farms across the country.
Several large CPG companies have indicated interest in partnering with their dairies and milk co-ops to reduce on-farm greenhouse gas emissions in their supply chains. The expected U.S. clearance of Bovaer will mark a significant milestone in opening up the next major market opportunity in animal health, livestock sustainability. We look forward to integrating Bovaer into our portfolio and expect to begin selling the product in the third quarter.
These three late-stage products, all with blockbuster potential, are very meaningful to Elanco's growth opportunity in the near and medium term and are expected to drive adjusted EBITDA growth over time. Based on the launch timing we shared today, the expected ramp curve and peak sales for all three products continue to support our goal of $600 million to $700 million of innovation revenue in 2025, with continued growth expected in the second half of the decade. We have an exciting few quarters ahead of us from a product approval and launch perspective. Meanwhile, Ellen de Brabander and her team remain focused on advancing all phases of the pipeline from refilling the early stage projects to progressing our later-stage programs.
We continue to believe that our IL-31 monoclonal antibody for canine dermatology will be approved in 2025, and we are progressing many differentiated assets in both research and development. We continue to see a robust pipeline supporting our ambition to deliver consistent, high-impact innovation. With that, I'll pass it to Todd to provide more on our first-quarter results and financial guidance.
Todd Young -- Chief Financial Officer
Thank you, Jeff, and good morning, everyone. Today, I will focus my comments on our first-quarter adjusted measures, so please refer to today's earnings press release for a detailed description of the year-over-year changes in our reported results. Starting on Slide 11. In the first quarter, we delivered $1.205 billion of revenue, a reported and constant-currency decline of 4%.
Price contributed 2% in the quarter. As Jeff referenced, the year-over-year comparisons for the first quarter are impacted by the ERP system blackout that occurred in 2023. Last year, we estimated sales of $90 million to $110 million shifted from the second quarter into the first quarter, reflecting a 7 to 9 percentage point detriment to growth in the first quarter of this year. With limited impact from foreign exchange rates, we estimate the underlying business grew 3% to 5%, slightly ahead of our expectations.
The estimated impacts are noted on Slide 12 for each business area. For pet health, constant-currency decline was 5%, with an estimated headwind to year-over-year growth of 10 to 12 percentage points from the ERP blackout. In the U.S., pet health revenue declined 8%, including a headwind to year-over-year growth of approximately 11 percentage points from the ERP blackout. The return to underlying growth was driven by price, resupply of certain vaccines that were out of stock last year, a one-time benefit related to moving certain legacy Bayer products into distribution and sales of new products.
In the quarter, the business also faced headwinds from the weather-impacted January, competitive innovation, and lower vet visits. Outside the U.S., our pet health business declined 3% in constant currency, with an estimated headwind to year-over-year growth of approximately 12 percentage points from the ERP blackout. Underlying growth in the quarter was driven by a return to more normalized demand patterns in Spain, ramp of innovation products led by AdTab, and higher demand for Credelio family products and Seresto across Europe. Globally, our farm animal business declined 3% in constant currency, with an estimated headwind to year-over-year growth of 4 to 5 percentage points from the ERP blackout.
In the U.S., our farm animal business grew 8%, with an estimated headwind to year-over-year growth of approximately 3 percentage points from the ERP blackout. The growth in the underlying business was driven by expanded Experior adoption, vaccine resupply, and demand for Elanco poultry products. Outside the U.S., our farm animal business declined 8% in constant currency, with an estimated headwind to year-over-year growth of approximately 6 percentage points from the ERP blackout. The decline in the underlying business was driven by weakness in Asian swine markets, partially offset by increased demand for poultry in Europe.
The majority of the year-over-year decline in the Aqua business was a result of the ERP blackout. Continuing down the income statement on Slide 13. Gross margin declined 350 basis points to 57.3%, in line with our expectations. The estimated impact on the year-over-year growth of gross margin from the ERP blackout was 130 to 200 basis points, as more sales of high-margin legacy Bayer animal health products were realized in the first quarter of 2023.
The remaining decline was driven by an approximate 170-basis-point headwind from slowing manufacturing output as we work to reduce balance sheet inventory and inflation, partially offset by price growth. Operating expenses increased 4% year over year in the quarter. R&D expenses increased $6 million, primarily driven by employee-related expenses and timing of project expenses. SG&A expense grew 3%, primarily driven by the expanded U.S.
pet sales force, increased promotional activity across targeted pet health brands, and employee-related expenses, partially offset by IT-related savings as a result of consolidating to one ERP system. Interest expense was $66 million, compared to $64 million last year. Additionally, other expenses declined from $11 million in the first quarter last year to $4 million this year, driven by our simplified operations in certain volatile markets, including Argentina. Moving to Slide 14.
Adjusted EBITDA was $294 million in the quarter. The year-over-year comparison is negatively impacted by an estimated $70 million to $90 million benefit from the ERP blackout in the first quarter of last year. For the underlying business, the decline was driven by higher sales, more than offset by our decision to increase commercial investments to drive long-term revenue growth in pet health. Adjusted EPS was $0.34 in the quarter.
The year-over-year comparison is negatively impacted by an estimated $0.11 to $0.14 benefit from the ERP blackout in the first quarter of last year. The slight increased underlying performance was primarily driven by a favorable tax rate. Before moving to our guidance, let me offer a few words on our cash, debt, and working capital on Slide 15. Cash from operations was $2 million in the quarter.
The $147 million year-over-year improvement in operating cash flow reflects improvement in inventory and savings from the reduction in project spend from the completion of our Bayer ERP integration. We ended the quarter with net debt of $5.466 billion, as we paid down $13 million of debt, enabled by improvements in both operating and investing cash flow. At the end of March, our net leverage ratio was 6.1 times, as our trailing 12-month EBITDA was negatively impacted by the ERP blackout from last year, which drove an estimated 0.4 to 0.6 turns of the increase. We continue to expect between $280 million and $320 million of free cash flow available for debt paydown this year.
We anticipate the year-end net leverage ratio to be between 5.2 and 5.5 times before considering the expected debt paydown from the net proceeds from the Aqua divestiture. We continue to expect net proceeds to be between $1.05 billion to $1.1 billion, which we intend to use primarily for debt paydown, leading to an expected net debt to adjusted EBITDA ratio in the mid four times range at the end of this year. Now, let's move to our financial guidance, starting on Slide 17. For the full year, we are tightening our guidance range to reflect first-quarter outperformance and the impact of the strengthening U.S.
dollar. We are raising the bottom end of our constant-currency revenue growth to 2%, and updating adjusted EBITDA and adjusted EPS to reflect FX rates as of early May. As a reminder, our guidance does not include contribution from our anticipated late-stage pipeline products and does not account for the expected impacts of the Aqua divestiture. On Slide 18, we provide further details on our updated revenue expectations.
The raised constant-currency growth is primarily driven by the U.S. farm animal and international pet health businesses, both from higher innovation sales and the base portfolio. The improved outlook also accounts for expected reduced sales for Kexxtone, a European cattle product. We have paused sales of the product while the manufacturing process is under review by the EMA.
We expect the full-year impact to be approximately $20 million of revenue and $18 million of adjusted EBITDA compared with our February guidance. Regarding FX, we now expect a $35 million headwind for the full year, $30 million higher than our February guidance. On Slide 19, we provide the bridge for adjusted EBITDA and adjusted EPS compared to our February guidance. We now expect adjusted EBITDA to be between $960 million to $1 billion, inclusive of an incremental $15 million headwind from the unfavorable impact of foreign exchange rates.
Excluding the FX impact, we are increasing the bottom end of our adjusted EBITDA guidance by $15 million and the top end by $5 million. Our improved constant-currency assumptions reflect the Q1 overperformance and increased confidence in the full year. For adjusted EPS, we are raising our expectations to $0.88 to $0.96 for the full year, despite unfavorable FX as a result of Q1 overperformance compared to our February guidance and improvements in both interest expense and tax. Slide 26 in the appendix provides updates to several of our additional assumptions.
On Slide 20, we provide our financial guidance for the second quarter. We expect revenue of $1.145 billion to $1.17 billion, adjusted EBITDA of $240 million to $260 million, and adjusted EPS of $0.23 to $0.26. As we shared last year and in the first quarter, as a result of the ERP system blackout in 2023, approximately $100 million of revenue, $80 million of adjusted EBITDA, and $0.13 of adjusted EPS shifted into the first quarter from the second quarter of 2023, which will impact the reported growth rates for the second quarter of 2024. As shown on Slide 21, the estimated headwind to year-over-year revenue growth from the ERP blackout in the first quarter will unwind, contributing approximately 9 to 11 percentage points to second-quarter revenue growth.
Excluding the estimated impact of the ERP blackout, we expect underlying constant-currency revenue growth will be 1% to 3%. The shift is also expected to positively impact year-over-year growth of adjusted EBITDA and adjusted EPS in the second quarter, as shown on Slide 22. In line with our results in the first quarter, our EBITDA expectations reflect manufacturing headwinds from slowing down the plants and increased investment in our pet health business. Overall, we are executing ahead of our initial expectations for the year and look forward to delivering on the opportunity to launch exciting new products later this year.
Now, I'll hand it back to Jeff for closing comments.
Jeff Simmons -- President and Chief Executive Officer
Thanks, Todd. This is a very exciting time in Elanco, and we have momentum across our business. Our global team is highly engaged, intensely focused, and deeply committed to building on the positive trajectory we've set over the past three quarters. The strategic actions taken to sharpen our focus and invest in our commercial growth drivers are delivering results.
Our focus on consistent high-impact innovation is driving immense progress. We have two potential blockbusters, experienced CPMA already in the market, with three more expected in the coming months. With these and our IL-31 product that's slated for next year, we are on track to deliver meaningful growth from innovation sales over the next several years. As we enter this pivotal moment in Elanco's trajectory, the stability within our leadership team and consistency of our strategy is paying off.
Our base business is growing, operating cash flow is improving, and contributions from new products are exceeding expectations. These factors, combined with the durability of our diverse portfolio and balanced geographic presence, give us the confidence to increase our expectations for constant-currency growth for the full year. Elanco is on track to deliver a strong 2024, and we look forward to continuing to engage with you all throughout the year. With that, I'll turn it over to Katy to moderate the Q&A.
Katy Grissom -- Head of Investor Relations
Thanks, Jeff. We'd like to take questions from as many callers as possible, so we ask that you limit yourself to one question and one follow-up. Operator, please provide the instructions for the Q&A session, and then we'll take the first caller.
Questions & Answers:
Operator
Thank you. At this time, we'll begin the question-and-answer session. [Operator instructions] We'll pause for just a moment while we compile the Q&A roster.
Katy Grissom -- Head of Investor Relations
We can go ahead and take the first question.
Operator
Thank you. Our first question comes from the line of Jon Block from Stifel. Please go ahead.
Jon Block -- Stifel Financial Corp. -- Analyst
Great, guys. Thanks and good morning. Jeff, interesting comments on the OTC para market. Why do you think the market's weak if the consumer is seemingly under pressure? Sometimes, that pressure causes a trade down.
And I just want to make sure I understand. It does seem like you're gaining share within that market performance even if we normalize for some of the stocking commentary. Maybe if you can elaborate on that. And then I'll just ask my follow-up.
For Zenrelia, it looks like you're going to compress the launch timing. Initially, you called out two to four months. It seems like it's going to move to something shorter than that. So, just what changed, or what will you change? Talk to us about your confidence there.
And then how do we think about the launch timing internationally for Zenrelia as well? Thanks for your time.
Jeff Simmons -- President and Chief Executive Officer
Yeah. Thanks, Jon. Let me start with that second question first. Again, Zenrelia, we're looking at technical sections approved.
As we said in the second quarter, the administrative process is 60 days typically, and that would go into the third quarter. As you know, we have been, and we've said very clearly that the production line and process for Zenrelia very much fits into what we do with other products like our parasiticides and made in our own facilities. So, we've been preparing. We have product that is manufactured that is ready.
Of course, we'll wait for the labeling, but we do believe that we've created additional efficiencies from the time from approval to launch. And that's why we have our current expectation is to bring that product to the market actually in Q3. So, that is our current plan. Relative to OTC, just real quickly, fundamentally, yes, we see strong demand for our OTC products.
That market is quite resilient even in the midst of some of the dynamics. We also, I think we see a little bit of the continuum pull back from -- after the innovation entered the market inside the vet clinic to we're seeing the more robust demand kind of coming back to the OTC products. Our portfolio is strong, and we've put our strategy to work which, I think, that's what's driving a lot of this is the expanded physical availability. We're now in club, dollar, grocery, the share of voice.
I think I really want to point to the Seresto -- seen probably the most jump in brand awareness on Seresto since owning the product and owning Bayer as we've seen unaided awareness up 5%. And a lot of that is the bolder campaign that I mentioned in my comments. And then we're constantly optimizing price volume. And then just overall, the innovation from the classic brands in the U.S.
to. Even, I want to note, AdTab is one of the fastest ramping products we have over in Europe in the retail market. But look, I think to your specific question, we saw the weather impact overall. We have seen some trade-down occur in the OTC space.
We now have a portfolio that can handle both the trade down as well as the premium products. So, that portfolio is playing out. And we've seen a pretty nice jump back. January weather took it down.
We've seen sequential improvement. We saw a 10% increase in March, actually, and we see that momentum carrying into the second quarter. So, again, omnichannel approach that we took when we purchased Bayer is paying off the strategy that Bobby and Ramiro have in place is paying off, and we continue to see this diversity as a really nice tailwind as we go into the vet clinic market now launching these new products.
Jon Block -- Stifel Financial Corp. -- Analyst
Thank you.
Operator
Thank you. Our next question comes from the line of Erin Wright of Morgan Stanley. Please go ahead.
Erin Wright -- Morgan Stanley -- Analyst
Great, thanks. Can you remind us -- I'll ask two upfront here because they're a little bit related. But can you just remind us on what's embedded in the guidance as it relates to the expenses associated with the upcoming blockbuster launches? And does this sort of increased certainty around of these launches, does that change how you're thinking about those investments that you're making ahead of those launches? And then second would be on your conversations with the FDA. And what changed or what are some of the next milestones that give you that sort of clarity on the launch timing? And for instance, could you actually see approval before those timelines? And would that change your launch timeline at all? Thanks.
Todd Young -- Chief Financial Officer
Erin, thanks for the question on the launch side. We feel very good about the timing as we've laid out today. The teams are preparing from training the sales force to preparing marketing materials to be ready to go. At the same time, the biggest cost is really TV ads and running those TV ads.
And so, we've not included those expenses in the guide, just like we haven't included the sales of Bovaer, Zenrelia, or Credelio Quattro into the guide. We continue to believe we'll be EBITDA-positive relative to the guidance we've laid out today. I'll turn it back to Jeff for the FDA question.
Jeff Simmons -- President and Chief Executive Officer
Yeah, Erin. I might just broaden your question a little bit, and I'll get to it. I think it's really important. I know innovation and these blockbuster products, specifically Zenrelia and Credelio, are important to all of us.
So, let me just add a little framing to the comments I made when I opened the call here. First, we are very pleased with the progress we've made in these key assets. Since February, actually, a lot of progress has happened, and that's driven our increased certainty as we move closer to the end of this approval process. Yes, the dialogue with the FDA has been rolling in iterative.
We've been in a productive engagement with them, Erin. It's been fair, constructive, frequent. And really, over the last several months, we've been responding to the questions from the agency, which is very common, I believe the Animal Drug User Fee Act, or ADUFA, is working specific on these assets. It's been constructive.
So, what's changed and what has not changed since February? What has changed is many sections and subsections of these submissions have been approved. Both products have progressed. Simply though, the back-and-forth interactions have taken slightly more time than when we estimated this path to first-half approval. Thus, we're not moving the final 60-day administrative review into the third quarter.
And I think importantly, we have increased certainty in the timing from all of this interaction that you mentioned. I think it's also important to say what hasn't changed. What hasn't changed is we continue to expect the products to be differentiated versus the current offering. We still expect all technical sections, including the label, to be approved in the first half or by the end of June.
And we expect that revenue contribution is still expected in the second half for these two products as well as Bovaer. And again, importantly, we believe the FDA has what they need for the approvals, and the launch planning, to your question on that, and the marketing is well underway. The U.S. pet health is well positioned right where we believe it needs to be relative to the launches.
We're as competitive as we've ever been. A good, nice lead indicators, engagement scores in U.S. pet health. They're as high as they've probably been in years and the highest, I think, in the global company.
So, that's a nice lead indicator that our preparedness is ready. We will launch as soon as possible as we've noted. We expect that right now to be Q3 for Zenrelia, Q4 for Credelio Quattro.
Katy Grissom -- Head of Investor Relations
Thanks. We'll take the next question.
Operator
Thank you. Our next question comes from the line of Michael Ryskin of Bank of America. Please go ahead.
Mike Ryskin -- Bank of America Merrill Lynch -- Analyst
Great. Thanks for taking the question, and congrats on the quarter and update. I'll ask both at the same time as well. So, following up on the new product approvals, especially Zenrelia and Quattro, you've been very transparent with us in terms of timing, both approval and launch in terms of expectations for label differentiation things like that.
As you get closer to the expected date, are you seeing any change in the marketplace from the existing players, Zoetis for derm and Zoetis in the eyes for Simparica Trio and NexGard Plus? Are they doing anything to build inventory? Are they having any different conversations with distributors or vets? I'm just wondering sort of how the market that you're going to be entering is evolving as you approach the sort of go-live date in 3Q, 4Q?And then my follow-up, which will be a little bit quicker, I hope, is going to be on Kexxtone, the EU update you provided. Seems like a pretty meaningful flow-through there. So, obviously, it seems like you're just sort of cutting that off. Could you give us a little bit more color on what exactly happened in the EU? is there any chance that comes back at some point? Just sort of what we should look forward from that next six, 12 months? Thanks.
Jeff Simmons -- President and Chief Executive Officer
Yeah. Very good questions, John. Thank you.
Katy Grissom -- Head of Investor Relations
Mike, Mike.
Jeff Simmons -- President and Chief Executive Officer
Excuse me, Mike. I'm sorry, Mike.
Mike Ryskin -- Bank of America Merrill Lynch -- Analyst
Thanks, Katy.
Jeff Simmons -- President and Chief Executive Officer
Sorry about that. So, listen, Mike, real quick. Look, we do anticipate and we see competitive reactions in the marketplace. And this marketplace has seen a lot of innovations come.
And we've made a lot of decisions over the last couple of years relative to launch. We've taken this very seriously. This is not new. We've been preparing for some time.
And we've had a lot of products to be testing and building the muscle of launch from Zorbium, Bexacat, now parvo. And so, I would say we're really well prepared. And so, look, I think the first thing that I would emphasize is it comes back to a couple of basics, share of voice to create clinic awareness that then leads to clinic penetration. That's why we've added the sales force.
Our share of voice metrics are high. They've grown dramatically the last two quarters. That's a key lead indicator that we're looking at. We know that's important.
And it's with credible, experienced people that have a lot of deep relationships and territories. That's key number one. And then look, the differentiation. We're working to optimize these labels because we know differentiation also impacts adoption.
I also would note this four-pillar approach we've talked about. And that's why derm for us really helps. It will help Quattro, but it will also help Zenrelia and our existing portfolio to be able to say, have therapeutics, vaccines, derm now, and parasiticides. So, I point to those things as well as what we're kind of calling next-generation sales and launch from digital to campaigns.
The thing I would note, too, on derm because it's all accretive to us, it's new. It's a big market. We're excited about Zenrelia. We're also excited about the IL-31 that's coming is, look, a few things I look to.
The derm market is large, it's growing meaningfully not just in international but U.S. And even this last quarter, we expect it to be differentiated, Zenrelia. And our market research continues to indicate vets are looking for more options. So, this will be a key fourth pillar for us on our offering that we believe puts us in a really good place.
And as I mentioned, the engagement is high. And going back to the earlier question, Zenrelia, globally, we are positioned to see Zenrelia come into the marketplace, we believe, late this year in some of the international markets to be our fastest global launch ever. So, that's a little bit of the launch side. Jumping to Kexxtone.
Kexxtone, a key cattle product in Europe. It's a controlled-release capsule that treats ketosis in the rumen of cattle. This is about a manufacturing process. It is a key product.
We have taken this product off the market. And our focus -- and we did that with the EMA, and we believe that our manufacturing team is working very hard on the manufacturing process. We see the product coming back to the market but don't anticipate that probably until late into 2025. And that's why we felt it was prudent to highlight that product and the removal on the market.
Todd Young -- Chief Financial Officer
And, Mike, the impact is both gross margin but also some inventory write-offs as well.
Katy Grissom -- Head of Investor Relations
Thanks. We'll take the next question.
Operator
Thank you. Our next question comes from the line of Balaji Prasad of Barclays. Please go ahead.
Katy Grissom -- Head of Investor Relations
Balaji, it looks like we are not hearing you. Let's go on to the next caller, and then we'll get them back in the queue.
Operator
Certainly. Our next question comes from the line of Umer Raffat of Evercore. Please go ahead.
Mike DiFiore -- Evercore ISI -- Analyst
Hi, good morning, guys. This is Mike DiFiore in for Umer. Thanks so much for taking my question. Two for me.
I'll ask the first one first. Regarding bundling. You've consistently said that having a derm asset in your portfolio will greatly enhance your bundling capabilities and, therefore, enhance your competitiveness in pet health. My question is, have those bundling discussions happened yet? Or do you need to wait for launch and pricing to kind of get established? I mean, you mentioned in your prepared remarks that you continue to solidify partnerships with corporate accounts? And then I have a follow-up.
Jeff Simmons -- President and Chief Executive Officer
Yeah, Mike. That's exactly right. I mean, this is quite common in the marketplace is any vet practice, whether they're corporate or general practitioner, is only going to carry a certain number of products. And as you bring in a wider portfolio as a company, that's going to help across the board.
That fundamental kind of principle plays out no matter what the size of the clinic. And then as you get to other groups that are larger corporately, there's no question. Having another alternative on the derm side is going to help overall and the market research shows that there's a high interest in that. So, those two principles play out, Mike, and we see that happening today and a high desire for more of that going forward.
Todd Young -- Chief Financial Officer
Yeah, Mike. We provide incentives to all of our customers based off volumes they purchase from us. So, by them being able to purchase derm from us now, that just gives them more ability to get savings and also then incentives to buy other products from us as they increase that volume. So, that's really the incentive structure we're talking about by having a full portfolio and being only one of the four major companies to have that in the U.S.
vet side.
Mike DiFiore -- Evercore ISI -- Analyst
Got it. That's helpful. And then my follow-up question is a brief one, and I may have missed this. Could you quantify how much of the one-time Bayer channel stocking amounted to in the quarter?
Todd Young -- Chief Financial Officer
It was about $10 million to $15 million.
Mike DiFiore -- Evercore ISI -- Analyst
Fifteen? OK.
Katy Grissom -- Head of Investor Relations
Thanks. We'll take the next caller.
Operator
Thank you. Our next question comes from the line of Ekaterina Knyazkova from JPMorgan. Please go ahead.
Ekaterina Knyazkova -- JPMorgan Chase and Company -- Analyst
Hey, thank you so much. So, first question is on Bovaer. Can you just remind us where you stand at this point in terms of manufacturing capacity and how we should think about capacity also for 2025 and where the implications and kind of think about the launch of that product? And then the second question is just on the bird flu epidemic in the U.S. Any thoughts on how that could impact producers? And anything that you're watching or particularly concerned about? Thank you so much.
Jeff Simmons -- President and Chief Executive Officer
Yeah. Thank you for the question. On Bovaer manufacturing, we have product here in the United States that is ready to be labeled. And it's bagged, ready to go, and that has been purchased from a partnering contract manufacturer in Europe.
So, we do have product ready. And again, that's why we've targeted a Q3 launch of the product. And then relative to the H5N1, we're continuing to monitor this closely, work with our customers to make sure there's heightened biosecurity measures. I think a couple of things we look to -- and we don't see this issue increasing over the last couple of weeks but pretty stable.
It is something we want to keep our eyes on. I think producer profitability and also especially the dairy consumer response are the lead indicators that we'll keep our eyes on. And I'll just emphasize, overall, we've not seen and do not see any impact on our business results at this point in time from the H5N1.
Katy Grissom -- Head of Investor Relations
Great. Thanks. We'll take the next caller.
Ekaterina Knyazkova -- JPMorgan Chase and Company -- Analyst
Thank you.
Katy Grissom -- Head of Investor Relations
Thanks.
Operator
Thank you. Our next question comes from the line of Brandon Vazquez from William Blair. Please go ahead.
Brandon Vazquez -- William Blair and Company -- Analyst
Hi, everyone. Thanks for taking the question. First on guidance. It was really encouraging.
You guys put up a nice speed here and then raised the guidance a little bit, especially in uncertain macro times. Can you just talk about what, so far, in the first quarter specifically is kind of outperforming that gives you confidence in raising that guidance, especially also on the EPS line? I think on top of FX headwinds, you're still able to increase it just about a penny or so. And then the follow-up is just a quick clarification on the pipeline. I think in the prepared remarks, you mentioned that you think you can get one-month heartworm efficacy with Quattro.
Can you just confirm, is that because the FDA has already approved that? Or is that just how the clinical data is looking and you feel comfortable that you will get approval for that? Thank you.
Todd Young -- Chief Financial Officer
Hey, Brandon. Thank you for the question. Q1 was really great performance by our U.S. farm business.
We're seeing accelerating adoption of Experior and with that, continued growth in Rumensin. This is the portfolio effect we talked about with having broad-based solutions for our customers, both on the pet side and the farm side, is by bringing those together, we continue to get ability to offset generic competition and drive growth. Poultry was really strong, and we've got a PRRS vaccine called Prevacent that continues to do very well in the U.S. farm market.
Then it was really international pet continue to see strong momentum both in Brazil as well as in Europe. AdTab, as Jeff mentioned earlier, is doing a great job of gaining sales across the European countries as it launches. And what we're seeing is less cannibalization of our topicals and collars in Europe from that launch than we originally expected. So, those are the big drivers of our confidence to raise the constant-currency guidance.
At EPS, one, better cash performance than we expected in Q1. Team has done a really good job of focusing on improving our net working capital and delivering on cash. That allowed us not to borrow cash in Q1, which we typically do as we pay our corporate bonuses as well as some other sort of seasonal effects with rebates. That means we don't have to pay interest on that borrowing for the rest of the year.
That allows us to reduce interest expense. And then finally, on the taxes, the tax credits we're receiving from the state of Indiana is allowing us to have a little better tax expectations than we thought originally and pick up a penny there on the full-year guide. With that, I'll transfer to Jeff for the second half of your question.
Jeff Simmons -- President and Chief Executive Officer
Yeah. Thank you, Brandon. Relative to Quattro, that is correct. We've said early on that we have passed the heartworm threshold.
So, to have heartworm control with -- at high parameter that the CBM has. And yes, we're making an assumption on the one-month control from the data package that we've submitted as well as the dialogue that we've had with the CBM. Thank you.
Katy Grissom -- Head of Investor Relations
Thanks. We'll take the next caller.
Operator
Thank you. Our next question comes from the line of Nathan Rich of Goldman Sachs. Please go ahead.
Nate Rich -- Goldman Sachs -- Analyst
Hi. Good morning, and thanks for the questions. I had a few on the derm products, and I'll ask them upfront. On the international approvals for Zenrelia, it seems like the timing may be shifted a little bit earlier than what you anticipated.
I guess, any details on what changed there? And are there certain markets where approval is expected before year-end? And then also on the IL-31 monoclonal antibody, I know the timing was unchanged on the slide, but I think the submission was made maybe a quarter after Zenrelia. Is there any difference in sort of the time line of review by the USDA versus the FDA that we should keep in mind in terms of when, in 2025, we might see that product approved?
Jeff Simmons -- President and Chief Executive Officer
Yeah. Thank you for the question. Relative to -- let me just hit the IL-31 first. We just confirmed that this product is expected in 2025.
And that's all we've noted. We've made nice progress since, and we're just highlighting that that's going to be part of the 600 million to 700 million and a key contribution to our derm portfolio. Internationally for Zenrelia, this is something that we've been working hard on, relative to as Bayer came in, it built greater presence, more pet presence, more regulatory as well presence, and all of that just to increase the capability of regulatory submissions quicker. And then Ellen's team has worked hard in terms of globalizing those packages and then customizing them into key countries.
And then we've added Tim Bennington on the marketing side, really being able to target which markets matter especially earlier. All of those things have come together to really accelerate. We haven't noted specifically, but you can imagine, these are the big pet markets, the submissions have been made. And from the dialogues with the regulatory authorities, we're confident that we're going to see this product come into international markets in Q4, all really as an outcome from the capabilities that we've built over the last two years on global regulatory.
Nate Rich -- Goldman Sachs -- Analyst
Thank you.
Katy Grissom -- Head of Investor Relations
Thanks. We'll take the next caller.
Operator
Thank you. Our next question comes from the line of David Westenberg of Piper Sandler. Please go ahead.
Dave Westenberg -- Piper Sandler -- Analyst
Hi. Thanks for taking the question, and congrats on the quarter. Just a couple on the innovations front. First on the Quattro product.
Can you talk about a little bit on the white space for the product specifically? And then maybe just kind of talk about the category growth, namely, I'm just kind of thinking, if we see Quattro play out, the differentiation on the tapeworm, broader coverage. Are we seeing this as taking share from other broad spectrum parasiticides? Are we seeing this growing from the old-generation oral parasiticides, or you just kind of see this as more of a market -- taking market growth from maybe topicals, OTC, that kind of product? And then just secondly, on the injectable or monoclonal derm. These products have been in the pipeline of Kindred. Of course, it was not -- you guys only inherited that later.
Is there something that you had to fix? Is there other kind of products? I know they had an IL-4 that could be coming in maybe 2026, 2027, maybe not ready to talk about pipeline, but I'd be curious because I do think those injectable derms have incredibly good market potential. Thank you.
Jeff Simmons -- President and Chief Executive Officer
Yeah. Thank you for the questions. Great, great questions. Let me just start with that derm product.
Yes, there was lots of work to do relative to the technologies inside of Kindred Bio where we're very happy with that acquisition, the manufacturing plant that's come with it. It's now making parvo and will make the other monoclonal antibodies as well. And we continue to progress the pipeline. We've not noted a lot of details relative to that, but as we've highlighted, we do have a long-acting and we do have the next generation of derm products to follow behind that.
And Kindred's portfolio will play into that. But there was continued work to do. And as we've noted, the USDA had asked us to increase the number of dogs and the number of treatments. And so, that actually is what extended the timeline.
It wasn't product specific. It was really requirement specific. Relative to the parasiticide market, it's a great question. Look, this is the largest market in animal health.
And a couple of principles play out very consistently as it's seen the most innovation come in. First is innovation usually increases the size of the market. We've seen that over the last couple of innovations that have come in recently. We believe our innovation will do the same.
The second is you see legacy innovation get impacted the soonest and the most rapidly. And we've seen that in our own portfolio, and Heather's have as well. So, we see that as important. The third one is the oral broader spectrum is growing the fastest.
So, when you combine these three things together, we believe Quattro, having the broadest coverage, being differentiated, combined with our omnichannel approach inside the clinic and being able to drop ship it to homes and to have this four-pillar approach with Zenrelia, it puts Quattro in a very strong position. Why wouldn't you want the broadest coverage if it's available. And we believe that we have that, and we have Credelio brand awareness that continues to climb across the marketplace. So, these are all factors that we play as we bring the broadest coverage product into the largest animal health market here over the second half of this year.
And we're excited to do that.
Katy Grissom -- Head of Investor Relations
All right. Thanks. We'll take the next one.
Operator
Thank you. Our next question comes from the line of Steven Scala from TD Cowen. Please go ahead.
Chris LoBianco -- TD Cowen -- Analyst
Hi. This is Chris on for Steve Scala. We just had one question on the technical approval aspect. So, what level of risk is associated with FDA administrative review once technical group was granted? Can you undertake any launch and promotional activities once technical approval is granted? And finally, will you disclose once those technical approvals are granted, hopefully in June?Thank you.
Jeff Simmons -- President and Chief Executive Officer
Yes. We will wait, of course, for final approval, and final approval is when everything will be public on label. And so, there's nothing that will come between the technical sections being approved and the final approval that is after that 60-day administrative side. And then relative to informing, if and when we have material news on any of these products, we will share promptly and appropriately.
Thank you.
Operator
Thank you. Our next question comes from the line of Navann Ty of BNP Paribas. Please go ahead.
Navann Ty -- Exane BNP Paribas -- Analyst
Hi, good morning. I have two questions, please. The first one on innovation. So, from your early discussions of the sales force, we've tried to discuss upcoming innovations, do you expect incrementally stronger pricing power with the higher relevance of Elanco's portfolio? And then I have a separate question on activist investor.
If you could discuss your dialogue and interactions with Ancora to date and since the appointment of Turner and Wallace to the board since late March. Thank you.
Jeff Simmons -- President and Chief Executive Officer
Thank you for the questions. As we've said with launching, we will look at this holistically. We will take, of course, we know that the market rewards innovation on the pet side especially, and we will take a value-based approach, a holistic approach, looking at not only the product and the differentiation of the new innovation but also the portfolio. And we will -- as Todd mentioned earlier, we will also look at this from the standpoint of offering now all four pillars of the portfolio into certain clinics.
We will look at potentially volume opportunities, but we'll take a value-based approach on the pricing side of the products. Relative to investors and the investor that you mentioned, our focus here is that we've come to an agreement that we've publicly communicated, and that was all around the principle of keeping the energy inside the company with a concentrated focus to execute against this value agenda that's in front of us. And that was that was the rationale behind the decision, and we're happy to continue to be executing as we go into the rest of 2024.
Katy Grissom -- Head of Investor Relations
Thanks. We'll take the last caller.
Operator
Thank you. Our last question for the day comes from Balaji Prasad of Barclays. Please go ahead.
Balaji Prasad -- Barclays -- Analyst
All right. Good morning, and thank you for having me back again. So a couple for me. Firstly, on the significance of technical approval and an administrative review.
Is this goal for any of the technical approvals to be rescinded during this administrative review period? And can you clarify what exactly happens here? One. Two, on the parasiticide side, obviously, we have seen your competitor post a very strong number on Simparica Trio. Trying to gauge what part of this is from the market expansion or market dislocation and what you have seen within the parasiticides market. And kind of linked to this is, any incremental color on the label expectations from your discussions with FDA? Thank you.
Jeff Simmons -- President and Chief Executive Officer
Yeah, Balaji. Thanks for the questions. On the regulatory process, there's always nuances and changes. But as we've highlighted, we believe the CBM has all the information that they need for approval.
We are on a path, we believe, for the technical sections to be approved by the end of June. And then the administrative process will follow. And typically, the administrative process is pretty straightforward. And on the ADUFA timeline, it's noted for 60 days.
And we do not expect any other new dynamics there. And then relative to the Trio market and market growth, as I've highlighted, and we won't get into any more detail than we've already disclosed relative to our Quattro label, but we do believe the broader coverage is valued in the marketplace. We do believe our capability with one of the broadest inside the vet clinic, outside the vet clinic parasiticide capabilities globally gives us great opportunity here. And the market is desiring this as you see in the shift.
So, thank you again for the question.
Katy Grissom -- Head of Investor Relations
And we'll -- Jeff, I'll send it to you to close.
Jeff Simmons -- President and Chief Executive Officer
Yeah. Just very quickly. Thank you. Thanks for your interest in Elanco.
We continue to say inside the company and outside the company the three key drivers for this company through '24 and '25 is growth, innovation, cash. And I believe this quarter, again, showed proof points, really for the third quarter in a row, third consecutive quarter of nice solid growth from our diverse portfolio, both farm animal, pet health, U.S. international, and even price and volume. On the innovation side, I really want to note the existing innovation, $100 million in the quarter.
We've got nice momentum in innovation. We're increasing our guide there. And our late-stage, we highlight increased certainty and the proof points that we noted all the progress in February. And then as Todd has mentioned, as inventories come down, networking capital has gone up and the cash conversion is on track and the Aqua sale for midyear is also tracking.
So, -- and ultimately, I think inside Elanco, engagement is high. Our energy is on executing quarter to quarter. We've delivered another quarter and our focus is to continue to do that going forward and keep anchoring back to growth, innovation, and cash. Thank you again for the time today.
We look forward to engaging with you throughout the quarter.
Operator
[Operator signoff]
Duration: 0 minutes
Call participants:
Katy Grissom -- Head of Investor Relations
Jeff Simmons -- President and Chief Executive Officer
Todd Young -- Chief Financial Officer
Jon Block -- Stifel Financial Corp. -- Analyst
Erin Wright -- Morgan Stanley -- Analyst
Mike Ryskin -- Bank of America Merrill Lynch -- Analyst
Mike DiFiore -- Evercore ISI -- Analyst
Ekaterina Knyazkova -- JPMorgan Chase and Company -- Analyst
Brandon Vazquez -- William Blair and Company -- Analyst
Nate Rich -- Goldman Sachs -- Analyst
Dave Westenberg -- Piper Sandler -- Analyst
Chris LoBianco -- TD Cowen -- Analyst
Navann Ty -- Exane BNP Paribas -- Analyst
Balaji Prasad -- Barclays -- Analyst
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